DECIPHERING INTRINSIC AND ADAPTIVE RESISTANCE TO PI3K PATHWAY INHIBITORS IN GLIOMA
نویسندگان
چکیده
منابع مشابه
PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers.
The RAS pathway is one of the most frequently deregulated pathways in cancer. RAS signals through multiple effector pathways, including the RAF/mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK MAPK and phosphatidylinositol 3-kinase (PI3K)-AKT signaling cascades. The oncogenic potential of these effector pathways is illustrated by the frequent ...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2014
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/nou208.56